@Article{096504017X14920318811695,
AUTHOR = {Jun-Ying Wang, Xin Jin, Xiao-Feng Li},
TITLE = {Knockdown of TMPRSS3, a Transmembrane Serine Protease,  Inhibits Proliferation, Migration, and Invasion in Human  Nasopharyngeal Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {1},
PAGES = {95--101},
URL = {http://www.techscience.com/or/v26n1/56621},
ISSN = {1555-3906},
ABSTRACT = {TMPRSS3 belongs to the large type II transmembrane serine protease (TTSP) family, which plays an important 
role in the development and progression of tumors. However, the function of TMPRSS3 in nasopharyngeal 
carcinoma (NPC) remains unclear. The present study aimed to examine the impact of TMPRSS3 on the proliferation, migration, and invasion of NPC cells and their potential mechanisms. Our results demonstrated that 
the expression of TMPRSS3 was obviously upregulated in human NPC tissues and cell lines. Knockdown of 
TMPRSS3 expression significantly suppressed the proliferation and tumorigenicity of NPC cells in vitro and in 
vivo. Furthermore, knockdown of TMPRSS3 inhibited migration and invasion, as well as prevented the EMT 
process in NPC cells. Finally, knockdown of TMPRSS3 attenuated activation of the PI3K/Akt signaling pathway in NPC cells. Taken together, the present study demonstrates that the knockdown of TMPRSS3 inhibits 
proliferation, migration, and invasion in human NPC cells through the inactivation of the PI3K/Akt signaling 
pathway. This study suggests that TMPRSS3 may be a potential therapeutic target for the treatment of NPC.},
DOI = {10.3727/096504017X14920318811695}
}