TY  - EJOU
AU  - Sun, Yang 
AU  - Jin, Jun-Gong 
AU  - Mi, Wei-Yang 
AU  - Hao-Wu, 
AU  - Zhang, Shi-Rong 
AU  - Meng, Qiang 
AU  - Zhang, Shi-Tao 

TI  - Long Noncoding RNA UCA1 Targets miR-122 to Promote Proliferation,  Migration, and Invasion of Glioma Cells
T2  - Oncology Research

PY  - 2018
VL  - 26
IS  - 1
SN  - 1555-3906

AB  - Glioma is the most common and lethal malignant intracranial tumor. Long noncoding RNAs (lncRNAs) 
have been identified as pivotal regulators in the tumorigenesis of glioma. However, the role of lncRNA 
urothelial carcinoma-associated 1 (UCA1) in glioma genesis is still unknown. The purpose of this study was 
to investigate the underlying function of UCA1 on glioma genesis. The results demonstrated that UCA1 was 
upregulated in glioma tissue and indicated a poor prognosis. UCA1 knockdown induced by si-UCA1 significantly suppressed the proliferative, migrative, and invasive activities of glioma cell lines (U87 and U251). 
Bioinformatics analysis and luciferase reporter assay verified the complementary binding within UCA1 and 
miR-122 at the 3'-UTR. Functional experiments revealed that UCA1 acted as an miR-122 “sponge” to modulate glioma cell proliferation, migration, and invasion via downregulation of miR-122. Overall, the present 
study demonstrated that lncRNA UCA1 acts as an endogenous sponge of miR-122 to promote glioma cell 
proliferation, migration, and invasion, which provides a novel insight and therapeutic target in the tumorigenesis of glioma.
KW  - Glioma; Long noncoding RNAs (lncRNAs); Urothelial carcinoma-associated 1 (UCA1);  miR-122; Migration; Invasion

DO  - 10.3727/096504017X14934860122864