@Article{096504017X14924753593574,
AUTHOR = {Ruifang Zeng, Guolin Tan, Wei Li, Yanhong Ma},
TITLE = {Increased Expression of Cullin 3 in Nasopharyngeal Carcinoma  and Knockdown Inhibits Proliferation and Invasion},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {1},
PAGES = {111--122},
URL = {http://www.techscience.com/or/v26n1/56623},
ISSN = {1555-3906},
ABSTRACT = {This study aimed to investigate the clinical significance of cullin 3 expression in nasopharyngeal carcinoma 
(NPC), as well as to explore the regulatory mechanism of cullin 3 underlying the growth and metastasis of 
NPC cells. Our findings showed that the expression levels of cullin 3 were significantly increased in both NPC 
tissues and cell lines. A strong positive correlation was found between cullin 3 expression and the Ki-67-based 
proliferation index in NPC tissues. Moreover, cullin 3 overexpression was correlated with local relapse and 
distant metastasis in NPC patients. In vitro experiments showed that knockdown of cullin 3 caused a significant 
reduction in the proliferation of NPC cells, probably by inducing cell cycle arrest. In addition, downregulation 
of cullin 3 inhibited colony formation and the migratory and invasive capacities of NPC cells. The expression 
levels of PCNA and epithelial-to-mesenchymal transition (EMT)-related proteins were also meditated by cullin 
3 in NPC cells. Based on these findings, we demonstrated that cullin 3 plays a promoting role in the malignant 
progression of NPC and suggest that the cullin 3-based ubiquitin proteasome pathway may be used as a promising therapeutic target for NPC.},
DOI = {10.3727/096504017X14924753593574}
}