@Article{096504017X14837020772250,
AUTHOR = {Feng Guo, Yaquan Liu},
TITLE = {Knockdown of TACC3 Inhibits the Proliferation and Invasion  of Human Renal Cell Carcinoma Cells},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {2},
PAGES = {183--189},
URL = {http://www.techscience.com/or/v26n2/56629},
ISSN = {1555-3906},
ABSTRACT = {Transforming acidic coiled-coil protein 3 (TACC3) is a member of the TACC family and plays an important 
role in regulating cell mitosis, transcription, and tumorigenesis. However, the expression pattern and roles of 
TACC3 in renal cell carcinoma (RCC) remain unclear. The aim of this study was to investigate the role of 
TACC3 in RCC. We demonstrated overexpression of TACC3 in human RCC cell lines at both RNA and protein 
levels. Moreover, knockdown of TACC3 repressed RCC cell proliferation, migration, and invasion in vitro. 
In addition, knockdown of TACC3 inactivated PI3K/Akt signaling in RCC cells. Furthermore, knockdown 
of TACC3 significantly reduced tumor growth in xenograft tumor-bearing mice. Taken together, our findings 
showed that TACC3 was increased in human RCC cell lines, and knockdown of TACC3 inhibited the ability of 
cell proliferation, migration, invasion, and tumorigenesis in vivo. Therefore, TACC3 may act as a therapeutic 
target for the treatment of human RCC.},
DOI = {10.3727/096504017X14837020772250}
}