@Article{096504017X14944585873659,
AUTHOR = {Zhongjun Li, Junxiu Guo, Yujie Ma, Longbo Zhang, Zhixiong Lin},
TITLE = {Oncogenic Role of MicroRNA-30b-5p in Glioblastoma  Through Targeting Proline-Rich Transmembrane Protein 2},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {2},
PAGES = {219--230},
URL = {http://www.techscience.com/or/v26n2/56633},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRs) have been found to play promoting or suppressive roles in different human cancers. 
However, the exact regulatory mechanism of miR-30b in glioblastoma remains unknown. Here we have shown 
that the expression of miR-30b is significantly increased in glioblastoma tissues and cell lines. Moreover, a 
high expression of miR-30b is significantly associated with a shorter survival time for glioblastoma patients. 
Knockdown of miR-30b caused a significant reduction in the proliferation, migration, and invasion of U87 
and A172 cells. Proline-rich transmembrane protein 2 (PRRT2) was further identified as a novel target gene of 
miR-30b, and its protein expression is negatively regulated by miR-30b in U87 and A172 cells. Furthermore, 
PRRT2 is significantly downregulated in glioblastoma tissues and cell lines, and we found an inverse correlation between miR-30b and PRRT2 expression in glioblastoma tissues. In addition, inhibition of PRRT2 
reversed the suppressive effect of miR-30b downregulation on the malignant phenotypes of U87 and A172 cells. 
Accordingly, we demonstrated that miR-30b promotes glioblastoma cell proliferation, migration, and invasion 
via targeting PRRT2. Therefore, miR-30b may be used as a promising therapeutic target for glioblastoma.},
DOI = {10.3727/096504017X14944585873659}
}