TY  - EJOU
AU  - Li, ShiDong 
AU  - Yang, JiaMei 
AU  - Xia, Yubing 
AU  - Fan, QingXia 
AU  - Yang, Kun-peng 

TI  - Long Noncoding RNA NEAT1 Promotes Proliferation and Invasion  via Targeting miR-181a-5p in Non-Small Cell Lung Cancer
T2  - Oncology Research

PY  - 2018
VL  - 26
IS  - 2
SN  - 1555-3906

AB  - Long noncoding RNAs (lncRNAs) have been implicated in various biological processes and pathological conditions, including tumorigenesis. However, the exact roles of NEAT1 and its underlying mechanisms in nonsmall cell lung cancer (NSCLC) remain largely unclear. In the present study, lncRNA NEAT1 was detected to 
be significantly upregulated in NSCLC tissues and closely associated with advanced TNM stages, lymph node 
metastasis, distant metastasis, and poor prognosis. Further experiments revealed that lncRNA NEAT1 silencing 
inhibited cell proliferation and invasion in vitro. In addition, mechanistic analysis showed that lncRNA NEAT1 
upregulated the miR-181a-5p-targeted gene HMGB2 through acting as a competitive “sponge” of miR-181-
a-5p. In conclusion, our study suggested that lncRNA NEAT1 plays an oncogenic role in NSCLC progression 
and provides potential mechanisms by which lncRNA NEAT1 contributes to this disease.
KW  - Non-small cell lung cancer (NSCLC); Long noncoding RNAs (lncRNAs);  Nuclear-enriched abundant transcript 1 (NEAT1); miR-181a-5p; HMGB2

DO  - 10.3727/096504017X15009404458675