@Article{096504017X15067856789781,
AUTHOR = {Heming Li, Junfeng Li, Taisheng Yang, Shuwen Lin, Heng Li},
TITLE = {MicroRNA-433 Represses Proliferation and Invasion of Colon Cancer Cells  by Targeting Homeobox A1},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {2},
PAGES = {315--322},
URL = {http://www.techscience.com/or/v26n2/56643},
ISSN = {1555-3906},
ABSTRACT = {The aberrant expression of miR-433 has been validated in some types of cancers. However, the expression profile and the biological function of miR-433 on colon cancer are still elusive. This study was designed to investigate the function of miR-433 on the proliferation and invasion of colon cancer cells. We detected the expression 
of miR-433 in colon cancer tissues, adjacent normal tissues, and cell lines. CCK8 and Transwell assays were 
performed to explore the impact of miR-433 on colon cancer cell proliferation and invasion. The luciferase 
reporter assay was applied to identify the direct target of miR-433. The results demonstrated that miR-433 was 
downregulated in colon cancer tissues and cell lines when compared with the control. Overexpression of miR-
433 significantly suppressed the ability of colon cancer cell proliferation and invasion, whereas knockdown 
of miR-433 remarkably enhanced cell proliferation and invasion. Homeobox A1 (HOXA1) was identified as a 
target of miR-433, and it mediated the functions of miR-433 on colon cancer cells. To conclude, we revealed 
that miR-433 was downregulated in colon cancer, and it inhibited colon cancer cell proliferation and invasion 
by directly targeting HOXA1.},
DOI = {10.3727/096504017X15067856789781}
}