TY  - EJOU
AU  - Ji, Fei 
AU  - Wuerkenbieke, Delinaer 
AU  - He, Yan 
AU  - Ding, Yan 
AU  - Du, Rong 

TI  - Long Noncoding RNA HOTAIR: An Oncogene in Human Cervical Cancer  Interacting With MicroRNA-17-5p
T2  - Oncology Research

PY  - 2018
VL  - 26
IS  - 3
SN  - 1555-3906

AB  - Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are a class of significant regulators in various tumorigenesis processes. The lncRNA homeobox transcript antisense RNA (HOTAIR) has 
been reported to act as a functional lncRNA in cervical cancer development. The present study investigated 
the underlying mechanism of HOTAIR and miR-17-5p in cervical cancer tumorigenesis. The results showed 
that HOTAIR expression was significantly upregulated in both cervical cancer tissues and cell lines. Lossof-function experiments showed that HOTAIR knockdown inhibited the proliferation, migration, and invasion of cervical cells. In addition, miR-17-5p expression was downregulated in cervical cancer tissues and 
cell lines. Pearson’s correlation analysis indicated that miR-17-5p expression was negatively correlated to that 
of HOTAIR. Luciferase reporter assay revealed that miR-17-5p directly targeted HOTAIR 3'-UTR. Rescue 
experiments showed that miR-17-5p knockdown could reverse the tumor-suppressing effect caused by siHOTAIR transfection. In summary, our results reveal the tumor-promoting role of HOTAIR in cervical cancer 
via sponging miR-17-5p, providing a novel therapeutic target for future treatment of cervical cancer.
KW  - Cervical cancer; HOTAIR; Tumorigenesis; miR-7-5p

DO  - 10.3727/096504017X15002869385155