@Article{096504017X14953948675421,
AUTHOR = {Xiaowen Chen, Jianli Chen},
TITLE = {miR-3188 Regulates Cell Proliferation, Apoptosis, and Migration in Breast  Cancer by Targeting TUSC5 and Regulating the p38 MAPK Signaling Pathway},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {3},
PAGES = {363--372},
URL = {http://www.techscience.com/or/v26n3/56649},
ISSN = {1555-3906},
ABSTRACT = {This study intended to investigate the effects of miR-3188 on breast cancer and to reveal the possible molecular 
mechanisms. miR-3188 was upregulated and TUSC5 was downregulated in breast cancer tissues and MCF-7 
cells compared to normal tissue and MCF-10 cells. After MCF-7 cells were transfected with miR-3188 inhibitor, cell proliferation and migration were inhibited, whereas apoptosis was promoted. Luciferase reporter assay 
suggested that TUSC5 was a target gene of miR-3188. In addition, miR-3188 overexpression increased the 
p-p38 expression, while miR-3188 suppression decreased the p-p38 expression significantly. miR-3188 regulated breast cancer progression via the p38 MAPK signaling pathway. In conclusion, miR-3188 affects breast 
cancer cell proliferation, apoptosis, and migration by targeting TUSC5 and activating the p38 MAPK signaling 
pathway. miR-3188 may serve as a potential therapeutic agent for the treatment of breast cancer.},
DOI = {10.3727/096504017X14953948675421}
}