@Article{096504017X15017209042610,
AUTHOR = {Lei Ou, Dazhong Wang, Han Zhang, Qian Yu, Fangfang Hua},
TITLE = {Decreased Expression of miR-138-5p by lncRNA H19 in Cervical Cancer  Promotes Tumor Proliferation},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {3},
PAGES = {401--410},
URL = {http://www.techscience.com/or/v26n3/56652},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRNAs) play important roles in the carcinogenesis of cervical cancer. However, the expression 
and underlying mechanisms of miRNA in cervical cancer progression remain unclear. In the present study, our 
data showed that the expression of miR-138-5p was significantly downregulated in cervical cancer tissues, and 
decreased expression of miR-138-5p was correlated with advanced FIGO stage, poor differentiation, lymph 
node metastasis, and poor overall survival of cervical cancer patients. Function assays showed that overexpression of miR-138-5p reduced cervical cancer cell proliferation, arrested cells in the G<sub>0</sub>
/G<sub>1</sub> phase, and induced 
cell apoptosis in vitro. Remarkably, SIRT1 was confirmed as a direct target of miR-138-5p in cervical cancer, 
and miR-138-5p exerted the reduced tumor functions by suppressing SIRT1 expression. Moreover, we further 
identified that lncRNA H19 could act as a molecular sponge of miR-138-5p in cervical cancer progression. 
Taken together, these results suggested that miR-138-5p could suppress cervical cancer cell progression by 
targeting SIRT1.},
DOI = {10.3727/096504017X15017209042610}
}