@Article{096504017X14974834436195,
AUTHOR = {Shu Chen, Lianhua Jin, Shu Nie, Lizhi Han, Na Lu, Yan Zhou},
TITLE = {miR-205 Inhibits Neuroblastoma Growth by Targeting cAMP-Responsive  Element-Binding Protein 1},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {3},
PAGES = {445--455},
URL = {http://www.techscience.com/or/v26n3/56656},
ISSN = {1555-3906},
ABSTRACT = {Accumulating evidence indicates that microRNA-205 (miR-205) is involved in tumor initiation, development, 
and metastasis in various cancers. However, its functions in neuroblastoma (NB) remain largely unclear. Here 
we found that miR-205 was significantly downregulated in human NB tissue samples and cell lines. miR-205 
expression was lower in poorly differentiated NB tissues and those of advanced International Neuroblastoma 
Staging System stage. In addition, restoration of miR-205 in NB cells suppressed proliferation, migration, and 
invasion and induced cell apoptosis in vitro, as well as impaired tumor growth in vivo. cAMP-responsive elementbinding protein 1 (<i>CREB1</i>) was identified as a direct target gene of miR-205. Expression of an miR-205 mimic 
in NB cells significantly diminished expression of CREB1 and the CREB1 targets BCL-2 and MMP9. CREB1 
was also found to be upregulated in human NB tissues, its expression being inversely correlated with miR-205 
expression (<i>r</i> = −0.554, <i>p</i> = 0.003). Importantly, CREB1 upregulation partially rescued the inhibitory effects 
of miR-205 on NB cells. These findings suggest that miR-205 may function as a tumor suppressor in NB by 
targeting <i>CREB1</i>.},
DOI = {10.3727/096504017X14974834436195}
}