@Article{096504017X15035025554553,
AUTHOR = {Haitao Song, Yanwei Rao, Gang Zhang, Xiangbo Kong},
TITLE = {MicroRNA-384 Inhibits the Growth and Invasion of Renal Cell  Carcinoma Cells by Targeting Astrocyte Elevated Gene 1},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {3},
PAGES = {457--466},
URL = {http://www.techscience.com/or/v26n3/56657},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRNAs) are emerging as pivotal regulators in the development and progression of various 
cancers, including renal cell carcinoma (RCC). MicroRNA-384 (miR-384) has been found to be an important 
cancer-related miRNA in several types of cancers. However, the role of miR-384 in RCC remains unclear. 
In this study, we aimed to investigate the potential function of miR-384 in regulating tumorigenesis in RCC. 
Here we found that miR-384 was significantly downregulated in RCC tissues and cell lines. Overexpression of 
miR-384 significantly inhibited the growth and invasion of RCC cells, whereas inhibition of miR-384 had the 
opposite effects. Bioinformatic analysis and luciferase reporter assay showed that miR-384 directly targeted 
the 3'-untranslated region of astrocyte elevated gene 1 (AEG-1). Further data showed that miR-384 could 
negatively regulate the expression of AEG-1 in RCC cells. Importantly, miR-384 expression was inversely correlated with AEG-1 expression in clinical RCC specimens. Moreover, miR-384 regulates the activation of Wnt 
signaling. Overexpression of AEG-1 significantly reversed the antitumor effects of miR-384. Overall, these 
findings suggest that miR-384 suppresses the growth and invasion of RCC cells via downregulation of AEG-1, 
providing a potential therapeutic target for the treatment of RCC.},
DOI = {10.3727/096504017X15035025554553}
}