@Article{096504017X15105708598531,
AUTHOR = {Xinyang Lu, Zhiqiang Liu, Xiaofei Ning, Lunhua Huang, Biao Jiang},
TITLE = {The Long Noncoding RNA HOTAIR Promotes Colorectal  Cancer Progression by Sponging miR-197},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {3},
PAGES = {473--481},
URL = {http://www.techscience.com/or/v26n3/56659},
ISSN = {1555-3906},
ABSTRACT = {The long noncoding RNA HOX transcript antisense RNA (HOTAIR) has been found to be overexpressed in 
many human malignancies and involved in tumor progression and metastasis. Although the downstream target 
through which HOTAIR modulates tumor metastasis is not well known, evidence suggests that microRNA-197 
(miR-197) might be involved in this event. In the present study, the significance of HOTAIR and miR-197 in 
the progression of colorectal cancer was detected in vitro and in vivo. We found that HOTAIR expression was 
significantly increased in colorectal cancer cells and tissues. In contrast, the expression of miR-197 was obviously decreased. We further demonstrated that HOTAIR knockdown promoted apoptosis and inhibited cell 
proliferation, migration, and invasion in vitro and in vivo. Moreover, HOTAIR modulated the progression of 
colorectal cancer by competitively binding miR-197. Taken together, our study has identified a novel pathway 
through which HOTAIR exerts its oncogenic role and provided a molecular basis for potential applications of 
HOTAIR in the prognosis and treatment of colorectal cancer.},
DOI = {10.3727/096504017X15105708598531}
}