@Article{096504017X14982578608217,
AUTHOR = {Xiaoyan Wang, Yongguang Xu, Xinlei Chen, Jianmin Xiao},
TITLE = {Dexmedetomidine Inhibits Osteosarcoma Cell Proliferation  and Migration, and Promotes Apoptosis by Regulating miR-520a-3p},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {3},
PAGES = {495--502},
URL = {http://www.techscience.com/or/v26n3/56661},
ISSN = {1555-3906},
ABSTRACT = {This study aimed to investigate the effect of dexmedetomidine (DEX) on osteosarcoma (OS) cell line MG63 
and to explore the possible relationship between DEX and miR-520-3p in OS. The results showed that DEX 
could upregulate miR-520-3p, which directly targeted AKT1. Additionally, miR-520-3p also inhibited MG63 
cell proliferation and migration, promoted apoptosis, and suppressed protein expressions of AKT, p-AKT, 
p-mTOR, and p-ERK1/2. DEX can inhibit OS cell proliferation and migration and promote apoptosis by upregulating the expression level of miR-520a-3p. DEX may serve as a potential therapeutic agent in OS treatment, 
and miR-520a-3p may be a potential target in the therapy of OS.},
DOI = {10.3727/096504017X14982578608217}
}