@Article{096504017X15000784459799,
AUTHOR = {Hui Li, Huicheng Chen, Haibin Wang, Yilong Dong, Min Yin, Liang Zhang, Jia Wei},
TITLE = {MicroRNA-374a Promotes Hepatocellular Carcinoma Cell Proliferation  by Targeting Mitogen-Inducible Gene 6 (MIG-6)},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {4},
PAGES = {557--563},
URL = {http://www.techscience.com/or/v26n4/56668},
ISSN = {1555-3906},
ABSTRACT = {Hepatocellular carcinoma (HCC) is a disease with poor prognosis rates and ineffective therapeutic options. 
Previous studies have reported the involvement of mitogen-inducible gene 6 (MIG-6) as a negative regulator 
in tumor formation. MicroRNAs (miRNAs) play crucial roles in the development of different types of cancer. 
However, the underlying mechanisms of miRNAs in HCC are poorly understood. This study was aimed to 
investigate the role of miR-374a in HCC and its role in the regulation of expression of MIG-6. The results 
showed that MIG-6 overexpression significantly inhibited cell viability of HepG2 cells after 4 days posttransfection. Moreover, MIG-6 was a direct target of miR-374a, and the expression of MIG-6 was remarkably 
downregulated by the overexpression of miR-374a in HepG2 cells. Furthermore, we found that overexpression 
of miR-374a promoted cell viability; however, the protective effect was abolished by MIG-6 overexpression. 
In addition, overexpression of miR-374a activated the EGFR and AKT/ERK signaling pathways by regulation 
of MIG-6. Our findings suggest that miR-374a could promote cell viability by targeting MIG-6 and activating 
the EGFR and AKT/ERK signaling pathways. These data provide a promising therapeutic strategy for HCC 
treatment.},
DOI = {10.3727/096504017X15000784459799}
}