@Article{096504017X15044461944385,
AUTHOR = {Yu Sun, Kai Xu, Miao He, Guilian Fan, Hongming Lu},
TITLE = {Overexpression of Glypican 5 (GPC5) Inhibits Prostate Cancer Cell  Proliferation and Invasion via Suppressing Sp1-Mediated EMT  and Activation of Wnt/β-Catenin Signaling},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {4},
PAGES = {565--572},
URL = {http://www.techscience.com/or/v26n4/56669},
ISSN = {1555-3906},
ABSTRACT = {Glypican 5 (GPC5) belongs to the family of heparan sulfate proteoglycans (HSPGs). It was initially known as a 
regulator of growth factors and morphogens. Recently, there have been reports on its correlation with the tumorigenic process in the development of some cancers. However, little is known about its precise role in prostate 
cancer (PCa). In the present study, we explored the expression pattern and biological functions of GPC5 in PCa 
cells. Our results showed that GPC5 was lowly expressed in PCa cell lines. Upregulation of GPC5 significantly 
inhibited PCa cell proliferation and invasion in vitro as well as attenuated tumor growth in vivo. We also found 
that overexpression of GPC5 inhibited the epithelial–mesenchymal transition (EMT) and Wnt/β-catenin signaling activation, which was mediated by Sp1. Taken together, we suggest GPC5 as a tumor suppressor in PCa 
and provide promising therapeutic strategies for PCa.},
DOI = {10.3727/096504017X15044461944385}
}