@Article{096504017X15031557924141,
AUTHOR = {Xiaoling Wu, Zhiqin Yang, Huimin Dang, Huixia Peng, Zhijun Dai},
TITLE = {Baicalein Inhibits the Proliferation of Cervical Cancer Cells Through  the GSK3β-Dependent Pathway},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {4},
PAGES = {645--653},
URL = {http://www.techscience.com/or/v26n4/56677},
ISSN = {1555-3906},
ABSTRACT = {Baicalein, a flavonoid derived from the root of <i>Scutellaria baicalensis</i>, has been reported to possess multiple 
pharmacological activities, such as anticancer and anti-inflammatory properties. This study investigated the 
effect of baicalein in cervical cancer cells. Cell growth curve and MTT assay were performed and revealed 
that baicalein inhibited the proliferation of SiHa and HeLa cells in a dose-dependent manner. We further found 
that baicalein arrested the cell cycle of SiHa and HeLa cells at the G<sub>0</sub>/G<sub>1</sub> phase by suppressing the expression 
of cyclin D1 through the downregulation of phosphorylated protein kinase B (p-AKT) and phosphorylated 
glycogen synthase kinase 3β (p-GSK3β) according to FACS assays and Western blotting. Moreover, when 
CHIR-99021, a GSK3β inhibitor, was added to baicalein-treated SiHa cells, the expression of cyclin D1 was 
recovered, and cell proliferation was promoted. In conclusion, these data indicated that baicalein suspended the 
cell cycle at the G<sub>0</sub>/G<sub>1</sub> phase via the downregulation of cyclin D1 through the AKT–GSK3β signaling pathway 
and further inhibited the proliferation of SiHa and HeLa cervical cancer cells.},
DOI = {10.3727/096504017X15031557924141}
}