@Article{096504017X14982569377511,
AUTHOR = {Meng Yang, Xu Zhai, Tingting Ge, Chang Yang, Ge Lou},
TITLE = {miR-181a-5p Promotes Proliferation and Invasion and Inhibits  Apoptosis of Cervical Cancer Cells via Regulating Inositol  Polyphosphate-5-Phosphatase A (INPP5A)},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {5},
PAGES = {703--712},
URL = {http://www.techscience.com/or/v26n5/56683},
ISSN = {1555-3906},
ABSTRACT = {Expression of miR-181a-5p associates with the proliferation and progression of cancer cells via its targets. 
This study was designed to investigate the effect of miR-181a-5p and its target inositol polyphosphate-5-
phosphatase A (INPP5A) on the progression of cervical cancers. Upregulation of miR-181a-5p was revealed in 
the cervical cancer cell lines HeLa and SiHa in comparison with a normal cervical epithelium cell line End1/
E6E7 (<i>p</i><0.001). The inhibition and upregulation of miR-181a-5p in cervical cancer cell lines significantly 
reduced or increased cell proliferation and invasion capacity, accompanied with enhanced or reduced apoptosis 
(<i>p</i><0.05). Moreover, INPP5A overexpression significantly inhibited cell proliferation and invasion capacity 
and enhanced cell apoptosis. The target relationship of miR-181a-5p to INPP5A was demonstrated by both the 
results of the Dual-Luciferase Reporter Assay and the fact that the miR-181a-5p mimic attenuated INPP5A’s 
effect on cell proliferation, invasion, and apoptosis. To sum up, the overexpression of miR-181a-5p enhanced 
cell proliferation and invasion and inhibited apoptosis of cervical cancer cells by negatively targeting INPP5A. 
Therefore, inhibition of miR-181a-5p might benefit the inhibition of cervical cancer cell invasion.},
DOI = {10.3727/096504017X14982569377511}
}