@Article{096504017X15021536183535,
AUTHOR = {Chao Ma, Jinfeng Han, Dong Dong, Nanya Wang},
TITLE = {MicroRNA-152 Suppresses Human Osteosarcoma Cell Proliferation  and Invasion by Targeting E2F Transcription Factor 3},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {5},
PAGES = {765--773},
URL = {http://www.techscience.com/or/v26n5/56689},
ISSN = {1555-3906},
ABSTRACT = {MicroRNA-152 (miR-152) expression has been reported to be downregulated in osteosarcoma (OS). However, 
the role of miR-152 in OS is not well documented. In the present study, we aimed to explore the function and 
underlying mechanism of miR-152 in OS. We found that miR-152 was underexpressed in OS tissues and cell 
lines. Decreased miR-152 was inversely correlated with lymph node metastasis and advanced clinical stage. 
Overexpression of miR-152 significantly inhibited cell proliferation, colony formation, migration, and invasion 
of OS cells. Bioinformatics analyses showed that miR-152 directly targeted E2F transcription factor 3 (E2F3), 
as further confirmed by a dual-luciferase reporter assay. E2F3 expression was upregulated and inversely correlated with miR-152 expression level in human OS tissues. Moreover, the inhibitory effects of miR-152 on 
OS growth and invasion were attenuated by E2F3 overexpression. Taken together, our findings indicated that 
miR-152 reduced OS growth and invasion by targeting E2F3 and provided new evidence of miR-152 as a 
potential therapeutic target for OS.},
DOI = {10.3727/096504017X15021536183535}
}