@Article{096504017X15132494420120,
AUTHOR = {Lili Lv, Xiaodong Wang},
TITLE = {MicroRNA-296 Targets Specificity Protein 1 to Suppress Cell Proliferation  and Invasion in Cervical Cancer},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {5},
PAGES = {775--783},
URL = {http://www.techscience.com/or/v26n5/56690},
ISSN = {1555-3906},
ABSTRACT = {Cervical cancer is the third most commonly diagnosed malignancy and the fourth leading cause of cancer-related 
deaths in women worldwide. MicroRNA-296 (miR-296) is aberrantly expressed in a variety of human cancer 
types. However, the expression levels, biological roles, and underlying molecular mechanisms of miR-296 in 
cervical cancer remain unclear. This study aimed to detect miR-296 expression in cervical cancer and evaluate 
its roles and underlying mechanisms in cervical cancer. This study demonstrated that miR-296 was significantly downregulated in cervical cancer tissues and cell lines. Restoring the expression of miR-296 inhibited 
the proliferation and invasion of cervical cancer cells. Moreover, miR-296 directly targeted the 3'-untranslated 
regions of specificity protein 1 (SP1) and decreased its endogenous expression at both the mRNA and protein 
levels. Similar to induced miR-296 expression, SP1 knockdown suppressed the proliferation and invasion of 
cervical cancer cells. Besides, resumption expression of SP1 rescued the tumor-suppressing roles of miR-296 
in cervical cancer. These results indicated that miR-296 may act as a tumor suppressor in cervical cancer by 
directly targeting SP1. Therefore, SP1 may be developed as a therapeutic target for the treatment of patients 
with this malignancy.},
DOI = {10.3727/096504017X15132494420120}
}