@Article{096504017X15127309628257,
AUTHOR = {Nan Li, Hangyu Shi, Lu Zhang, Xu Li, Lu Gao, Gang Zhang, Yongqiang Shi, Shiwen Guo},
TITLE = {miR-188 Inhibits Glioma Cell Proliferation and Cell Cycle  Progression Through Targeting β-Catenin},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {5},
PAGES = {785--794},
URL = {http://www.techscience.com/or/v26n5/56691},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRNAs) play important roles in several human cancers. Although miR-188 has been suggested 
to function as a tumor repressor in cancers, its precise role in glioma and the molecular mechanism remain 
unknown. In the present study, we investigated the effect of miR-188 on glioma and explored its relevant 
mechanisms. We found that the expression of miR-188 is dramatically downregulated in glioma tissues and 
cell lines. Subsequent investigation revealed that miR-188 expression was inversely correlated with β-catenin 
expression in glioma tissue samples. Using a luciferase reporter assay, β-catenin was determined to be a direct 
target of miR-188. Overexpression of miR-188 reduced β-catenin expression at both the mRNA and protein 
levels, and inhibition of miR-188 increased β-catenin expression. Moreover, we found that overexpression of 
miR-188 suppressed glioma cell proliferation and cell cycle G<sub>1</sub>–S transition, whereas inhibition of miR-188 
promoted glioma cell proliferation. Importantly, silencing β-catenin recapitulated the cellular and molecular 
effects seen upon miR-188 overexpression, which included inhibiting glioma cell proliferation and G<sub>1</sub>–S transition. Taken together, our results demonstrated that miR-188 inhibits glioma cell proliferation by targeting 
β-catenin, representing an effective therapeutic strategy for glioma.},
DOI = {10.3727/096504017X15127309628257}
}