@Article{096504017X15016337254632,
AUTHOR = {Jifu Song, Zhibin Guan, Maojiang Li, Sha Sha, Chao Song, Zhiwei Gao, Yongli Zhao},
TITLE = {MicroRNA-154 Inhibits the Growth and Invasion of Gastric Cancer Cells  by Targeting DIXDC1/WNT Signaling},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {6},
PAGES = {847--856},
URL = {http://www.techscience.com/or/v26n6/56698},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRNAs) have emerged as pivotal regulators of the development and progression of gastric 
cancer. Studies have shown that miR-154 is a novel cancer-associated miRNA involved in various cancers. 
However, the role of miR-154 in gastric cancer remains unknown. Here we aimed to investigate the biological 
function and the potential molecular mechanism of miR-154 in gastric cancer. We found that miR-154 was significantly downregulated in gastric cancer tissues and cell lines. The overexpression of miR-154 significantly 
repressed the growth and invasion of gastric cancer cells. Bioinformatics analysis and Dual-Luciferase Reporter 
Assay data showed that miR-154 directly targeted the 3'-untranslated region of Dishevelled–Axin domain containing 1 (DIXDC1). Real-time quantitative polymerase chain reaction and Western blot analyses showed that 
miR-154 overexpression inhibited DIXDC1 expression. An inverse correlation of miR-154 and DIXDC1 was 
also demonstrated in gastric cancer specimens. Overexpression of miR-154 also significantly suppressed the 
activation of WNT signaling. Moreover, restoration of DIXDC1 expression significantly reversed the inhibitory effect of miR-154 overexpression on the cell proliferation, invasion, and WNT signaling in gastric cancer 
cells. Overall, these results suggest that miR-154 inhibits gastric cancer cell growth and invasion by targeting 
DIXDC1 and could serve as a potential therapeutic target for the treatment of gastric cancer.},
DOI = {10.3727/096504017X15016337254632}
}