@Article{096504017X15009419625178,
AUTHOR = {Yuanyuan Wang, Qin Luo, Xianlu He, He Wei, Ting Wang, Jichun Shao, Xinni Jiang},
TITLE = {Emodin Induces Apoptosis of Colon Cancer Cells via Induction  of Autophagy in a ROS-Dependent Manner},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {6},
PAGES = {889--899},
URL = {http://www.techscience.com/or/v26n6/56702},
ISSN = {1555-3906},
ABSTRACT = {Recent studies revealed that emodin extracted from Chinese herbs exhibits an anticancer effect on different cancer types, including colon cancer. However, the mechanism is not well understood. In our study, we 
confirmed that emodin treatment inhibited cell viability and induced apoptosis in colon cancer cells. Further 
experiments found that emodin was also able to induce autophagy, which is indispensible for apoptosis 
induced by emodin. More interestingly, emodin treatment also results in mitochondrial dysfunction and ROS 
accumulation in colon cancer cells. Finally, we stressed that ROS accumulation is essential for autophagy 
and apoptosis induced by emodin. In conclusion, emodin induces apoptosis in colon cancer cells through 
induction of autophagy, during which ROS generation is of the essence. Our findings improve understanding of emodin’s effect on colon cancer suppression and provide a new theoretical basis for colon cancer 
therapy.},
DOI = {10.3727/096504017X15009419625178}
}