@Article{096504017X15061902533715,
AUTHOR = {Jianjun Shen, Weina Niu, Hongbo Zhang, Ma Jun, Hongyan Zhang},
TITLE = {Downregulation of MicroRNA-147 Inhibits Cell Proliferation and Increases  the Chemosensitivity of Gastric Cancer Cells to 5-Fluorouracil by Directly  Targeting PTEN},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {6},
PAGES = {901--911},
URL = {http://www.techscience.com/or/v26n6/56703},
ISSN = {1555-3906},
ABSTRACT = {Gastric cancer is the fourth most common malignancy and the third leading cause of cancer-related deaths 
worldwide. This study aimed to investigate the expression patterns, biological roles, and underlying mechanisms of microRNA-147 (miR-147) in gastric cancer. The present study demonstrated that miR-147 was 
significantly upregulated in gastric cancer tissues and cell lines. Downregulation of miR-147 decreased cell 
proliferation and enhanced the chemosensitivity of gastric cancer cells to 5-fluorouracil (5-FU) through the 
cell apoptosis pathway. In addition, phosphatase and tensin homolog (PTEN) was mechanically identified as 
the direct target of miR-147 in gastric cancer. PTEN knockdown reversed the effects of miR-147 downregulation on the proliferation, chemosensitivity, and 5-FU-induced apoptosis of gastric cancer cells. Moreover, 
miR-147 regulated the PI3K/AKT signaling pathway in gastric cancer by targeting PTEN. In conclusion, 
miR-147 suppressed the proliferation and enhanced the chemosensitivity of gastric cancer cells to 5-FU by 
promoting cell apoptosis through directly targeting PTEN and regulating the PI3K/AKT signaling pathway. 
This study provides important insight into the molecular mechanism that underlies the chemoresistance of 
gastric cancer cells. The results of this study could aid the development of a novel therapeutic strategy for 
gastric cancer.},
DOI = {10.3727/096504017X15061902533715}
}