@Article{096504017X15135941182107,
AUTHOR = {Jianli Chen, Xiaowen Chen},
TITLE = {MYBL2 Is Targeted by miR-143-3p and Regulates Breast Cancer Cell  Proliferation and Apoptosis},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {6},
PAGES = {913--922},
URL = {http://www.techscience.com/or/v26n6/56704},
ISSN = {1555-3906},
ABSTRACT = {Breast cancer remains a public health issue on a global scale. The present study aimed to explore the functional role of MYB proto-oncogene like 2 (MYBL2) in breast cancer, as well as underlying mechanisms. 
The regulatory relationship between miR-143-3p and MYBL2 was analyzed, and the effects of dysregulation 
of miR-143-3p and MYBL2 on cell proliferation and apoptosis were investigated. The results showed that 
MYBL2 and miR-143-3p were inversely expressed in breast cancer tissues and cells: MYBL2 was highly 
expressed, whereas miR-143-3p was lowly expressed. MYBL2 was confirmed as a target gene of miR-143-3p. 
Suppression of MYBL2 inhibited proliferation and induced apoptosis of breast cancer cells, which was similar 
to the effects of overexpression of miR-143-3p. Our findings reveal that MYBL2 is targeted by miR-143-3p 
and regulates breast cancer cell proliferation and apoptosis.},
DOI = {10.3727/096504017X15135941182107}
}