@Article{096504017X15144741233346,
AUTHOR = {Xuesong Wang, Yong Lin, Lei Peng, Ruifu Sun, Xiaojin Gong, Jinlong Du, Xiugong Zhang},
TITLE = {MicroRNA-103 Promotes Proliferation and Inhibits Apoptosis in Spinal  Osteosarcoma Cells by Targeting p57},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {6},
PAGES = {933--940},
URL = {http://www.techscience.com/or/v26n6/56706},
ISSN = {1555-3906},
ABSTRACT = {Osteosarcoma is one of the most aggressive malignancies with poor prognosis rates. Many studies have demonstrated that miRNAs were involved in osteosarcoma, but the role of miR-103a in osteosarcoma remains elusive. 
In this study, we detected the expression levels of miR-103 in osteosarcoma and non-osteosarcoma tissues 
and cell lines. The binding effect of miR-103 on p57 was detected by luciferase reporter assay. After altering 
expressions of miR-103 or p57, viability, migration, invasion, and apoptosis of MG63 cells and expressions 
of proteins related with the JNK/STAT and mTOR pathways were all detected. We found the higher expression of miR-103 in osteosarcoma tissues and cell lines compared with non-osteosarcoma tissues and cell lines. 
miR-103 overexpression promoted survival, migration, and invasion of MG63 cells. Knockdown of miR-103a 
inhibited cell survival, migration, and invasion by upregulating the expression of p57, which was a target 
of miR-103. Moreover, miR-103a overexpression activated the JNK/STAT and mTOR pathways probably 
through inhibiting p57 expression. In conclusion, miR-103a acted as an oncogene in osteosarcoma, probably 
through activating the JNK/STAT and mTOR pathways by inhibiting p57 expression.},
DOI = {10.3727/096504017X15144741233346}
}