@Article{096504018X15149787144385,
AUTHOR = {Liqing Zhang, Jianjiang Xu, Gaodi Yang, Heng Li, Xiuxia Guo},
TITLE = {miR-202 Inhibits Cell Proliferation, Migration, and Invasion by Targeting  Epidermal Growth Factor Receptor in Human Bladder Cancer},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {6},
PAGES = {949--957},
URL = {http://www.techscience.com/or/v26n6/56708},
ISSN = {1555-3906},
ABSTRACT = {Recent studies have demonstrated that miR-202 is associated with several types of cancer; however, the expression 
and function of miR-202 have not been investigated in bladder cancer. We analyzed the expression of miR-202 in 
bladder cancer tissues and adjacent noncancerous tissues. The effect of miR-202 on the proliferation, migration, 
and invasion was evaluated by in vitro assays. The target gene of miR-202 was assessed by luciferase reporter 
assay. In this study, miR-202 was found to be significantly downregulated in bladder cancer cell lines and tissues 
and was highly correlated with the T classification, N classification, grade, and recurrence. Ectopic expression 
of miR-202 suppressed cell viability, colony formation, cell migration, and invasion in vitro and inhibited xenograft tumor growth in vivo. Inversely, downregulation of miR-202 had contradictory effects. The 3'-untranslated 
region (3'-UTR) of epidermal growth factor receptor (EGFR) was identified as a direct target of miR-202 using 
luciferase reporter assays, and knockdown of EGFR enhanced miR-202-inhibited cell proliferation, migration, 
and invasion. In conclusion, miR-202 suppresses bladder cancer carcinogenesis and progression by targeting 
EGFR, thereby representing a potential target for miRNA-based therapy for bladder cancer in the future.},
DOI = {10.3727/096504018X15149787144385}
}