TY  - EJOU
AU  - Shi, Xi 
AU  - Xiao,  
AU  - Yuan, Na 
AU  - Zhang, Shili 
AU  - Yuan, Fukang 
AU  - Wang, Xiaohong 

TI  - MicroRNA-379 Suppresses Cervical Cancer Cell Proliferation and Invasion  by Directly Targeting V-crk Avian Sarcoma Virus CT10 Oncogene  Homolog-Like (CRKL)
T2  - Oncology Research

PY  - 2018
VL  - 26
IS  - 7
SN  - 1555-3906

AB  - Cervical cancer is the fourth most common malignancy among females worldwide. MicroRNA-379 (miR-379) 
is aberrantly expressed in multiple human cancer types. However, the expression pattern, roles, and detailed 
regulatory mechanisms of miR-379 in cervical cancer remain unknown. In this study, we found that miR-379 
expression was downregulated in cervical cancer tissues and cell lines. Low miR-379 expression was correlated with International Federation of Gynecology and Obstetrics (FIGO) stage, lymph node metastasis, and 
distant metastasis. Additionally, miR-379 overexpression suppressed the proliferation and invasion of cervical 
cancer cells. Furthermore, V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL) was identified as 
a direct target of miR-379 in cervical cancer. CRKL was upregulated in cancer tissues and negatively correlated 
with miR-379 expression. Moreover, restored CRKL expression rescued the inhibitory effects of miR-379 
overexpression on cell proliferation and invasion. In conclusion, miR-379 may serve as a tumor suppressor in 
cervical cancer by directly targeting CRKL. Restoring miR-379 expression may be an effective strategy for the 
treatment of cervical cancer.
KW  - Cervical cancer; MicroRNA-379 (miR-379); Proliferation; Invasion;  V-crk avian sarcoma virus CT10 oncogene homolog-like (CRKL)

DO  - 10.3727/096504017X15140534417184