@Article{096504018X15151515028670,
AUTHOR = {Mao Guoping, Liu Ran, Qin Yanru},
TITLE = {miR-143 Inhibits Cell Proliferation of Gastric Cancer Cells  Through Targeting GATA6},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {7},
PAGES = {1023--1029},
URL = {http://www.techscience.com/or/v26n7/56716},
ISSN = {1555-3906},
ABSTRACT = {Recent studies have suggested that the dysregulation of microRNAs (miRNAs) plays a critical role in the progression of human cancers, including gastric cancer (GC). miR-143 had been reported to function as a tumor 
suppressor in GC. However, the exact molecular mechanism of how miR-143 participates in GC progression 
remains to be determined. In this present study, we revealed that the expression of miR-143 was significantly 
downregulated in human GC tissues and cell lines compared with normal tissues and a normal gastric epithelium cell line. In addition, upregulation of the expression of miR-143 in a GC cell line inhibited cell proliferation and induced cell cycle arrested in the G<sub>0</sub>/G<sub>1</sub> phase. Furthermore, GATA6 was identified as a direct target 
of miR-143 in GC using the luciferase reporter assay. Upregulation of miR-143 inhibited the expression of 
GATA6 in GC cell lines. Moreover, the overexpression of GATA6 could attenuate the effect of miR-143 on 
cell proliferation in the GC cell lines. Collectively, these data indicated that miR-143 plays a tumor suppressor 
role partly through regulating the expression of GATA6 in GC. Therefore, targeting miR-143 may be a novel 
therapeutic method for GC.},
DOI = {10.3727/096504018X15151515028670}
}