TY  - EJOU
AU  - Yuan, Gang 
AU  - Quan, Jingzi 
AU  - Dong, fang 
AU  - Wang, Qunying 

TI  - Long Noncoding RNA CAT104 Promotes Cell Viability, Migration, and Invasion  in Gastric Carcinoma Cells Through Activation of MicroRNA-381-Inhibiting  Zinc Finger E-box-Binding Homeobox 1 (ZEB1) Expression
T2  - Oncology Research

PY  - 2018
VL  - 26
IS  - 7
SN  - 1555-3906

AB  - Gastric carcinoma (GC) remains the second leading cause of cancer-related deaths worldwide. Good biomarkers are of paramount importance for GC therapy. This study aimed to assess the role of long noncoding RNA (lncRNA) CAT104 in GC. We found that CAT104 was highly expressed in human GC NCI-N87, 
SGC7901, BGC823, BGC803, and AGS cells. Suppression of CAT104 decreased NCI-N87 cell viability, 
migration, and invasion, but promoted apoptosis. CAT104 knockdown enhanced the expression of microRNA-
381 (miR-381) expression in NCI-N87 cells. miR-381 participated in the regulatory effects of CAT104 on 
NCI-N87 cell viability, migration, invasion, and apoptosis. Zinc finger E-box-binding homeobox 1 (ZEB1) 
was identified as a direct target of miR-381. Overexpression of ZEB1 reversed the miR-381 mimic- induced 
cell viability, migration, and invasion inhibition. Suppression of ZEB1 reversed the miR-381 inhibitor-induced 
activation of the c-Jun N-terminal kinase (JNK) pathway and Wnt/b-catenin signaling pathways in NCI-N87 
cells. In conclusion, CAT104 might function as an oncogenic factor in GC cells via regulating the expression 
of miR-381 and ZEB1.
KW  - Long noncoding RNA CAT104; Gastric carcinoma (GC); MicroRNA-381;  Zinc finger E-box-binding homeobox 1 (ZEB1); c-Jun N-terminal kinase (JNK) pathway;  Wnt/β-catenin pathways

DO  - 10.3727/096504017X15144748428127