@Article{096504018X15152072098476,
AUTHOR = {Xingquan Zhai, Wei Xu},
TITLE = {Long Noncoding RNA ATB Promotes Proliferation, Migration, and Invasion  in Bladder Cancer by Suppressing MicroRNA-126},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {7},
PAGES = {1063--1072},
URL = {http://www.techscience.com/or/v26n7/56721},
ISSN = {1555-3906},
ABSTRACT = {This study aimed to explore the biological functions of long noncoding RNA activated by transforming growth 
factor-b (lncRNA-ATB) in bladder cancer cells. For the expressions of lncRNA-ATB, miR-126, and KRAS, 
T24 cells were transfected with their specific vectors/shRNA or mimic/inhibitor. Then cell viability, migration, 
invasion, and apoptosis as well as the protein levels of apoptosis-related factors and PI3K/AKT and mTOR 
signal pathways were measured. The relationships of lncRNA-ATB and miR-126 or miR-126 and KRAS were 
analyzed by Dual-Luciferase Reporter assay. Functional experiments showed that lncRNA-ATB overexpression significantly promoted cell viability, migration, and invasion in T24 cells. lncRNA-ATB was a molecular 
sponge of miR-126 and exerted tumor-promoting effects by downregulation of miR-126. Moreover, KRAS 
was a direct target of miR-126 and was negatively regulated by miR-126. Finally, overexpression of KRAS 
increased cell viability, migration, and invasion, as well as activated PI3K/AKT and mTOR signaling pathways 
in T24 cells. The results revealed that lncRNA-ATB was an oncogene, which promoted cell proliferation, 
migration, and invasion by regulating miR-126 in bladder cancer. These findings may provide a potential prognostic biomarker and a therapeutic target for bladder cancer.},
DOI = {10.3727/096504018X15152072098476}
}