@Article{096504017X15145088802439,
AUTHOR = {Zhixian Guo, Jingjing Li, Jihong Sun, Lu Sun, Yubing Zhou, Zujiang Yu},
TITLE = {miR-346 Promotes HCC Progression by Suppressing Breast Cancer Metastasis  Suppressor 1 Expression},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {7},
PAGES = {1073--1081},
URL = {http://www.techscience.com/or/v26n7/56722},
ISSN = {1555-3906},
ABSTRACT = {Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. MicroRNA 
(miRNA), a class of noncoding single-stranded RNA molecules, is involved in regulating cancer cell proliferation, metastasis, migration, invasion, and apoptosis. We showed that the expression of miR-346 was significantly increased in HCC tissues and cell lines, compared with noncancerous controls, and was associated with 
poor prognosis. Overexpression of miR-346 promoted proliferation and inhibited apoptosis of SMMC-7721 
cells, while knockdown of miR-346 significantly suppressed proliferation and induced apoptosis of HepG2 
cells. Then we identified breast cancer metastasis suppressor 1 (BRMS1) as a direct target of miR-346 based on 
luciferase reporter assays. There was a negative correlation between miR-346 and BRMS1 expression at both 
the protein and mRNA levels. Furthermore, inhibition of BRMS1 expression reversed the tumor-suppression 
effects of miR-346 downregulation in HepG2 cells. These results indicate that miR-346 promotes HCC progression by regulating BRMS1 expression.},
DOI = {10.3727/096504017X15145088802439}
}