@Article{096504018X15154112497142,
AUTHOR = {Bo Hu, Xunbo Jin, Jianbo Wang},
TITLE = {MicroRNA-212 Targets Mitogen-Activated Protein Kinase 1 to Inhibit  Proliferation and Invasion of Prostate Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {7},
PAGES = {1093--1102},
URL = {http://www.techscience.com/or/v26n7/56724},
ISSN = {1555-3906},
ABSTRACT = {Prostate cancer (PCa) is the second most commonly diagnosed malignancy and the fifth leading cause of 
cancer-related deaths in males worldwide. MicroRNAs (miRNAs) may serve as important regulators in PCa 
occurrence and development. Therefore, understanding the expression and functions of PCa-related miRNAs 
may be beneficial for the identification of novel therapeutic methods for patients with PCa. In this study, 
miRNA-212 (miR-212) was evidently downregulated in PCa tissues and several PCa cell lines. Functional 
assays showed that the resumption of miR-212 expression attenuated cell proliferation and invasion and 
increased the apoptosis of PCa. In addition, mitogen-activated protein kinase 1 (MAPK1), a well-known oncogene, was identified as a novel target of miR-212 in PCa, as confirmed by bioinformatics, luciferase reporter 
assay, qRT-PCR, and Western blot analysis. Furthermore, MAPK1 expression was upregulated in PCa tissues and inversely correlated with miR-212 expression. Rescue experiments also demonstrated that restored 
MAPK1 expression reversed the tumor-suppressing effects of miR-212 on PCa cell proliferation, invasion, and 
apo ptosis. In conclusion, miR-212 may exert tumor-suppressing roles in PCa by regulating MAPK1 and could 
be a novel therapeutic target for treatment of patients with this malignancy.},
DOI = {10.3727/096504018X15154112497142}
}