@Article{096504018X15168461629558,
AUTHOR = {Xiaowei Shen,  Jianping Huang, Gang Liu, Hao Zhang, Xiwei Zhang, Xiancheng Kong, Lei Du},
TITLE = {Matrine Inhibits Neuroblastoma Cell Proliferation and Migration  by Enhancing Tribbles 3 Expression},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {7},
PAGES = {1133--1142},
URL = {http://www.techscience.com/or/v26n7/56728},
ISSN = {1555-3906},
ABSTRACT = {Neuroblastoma is a major contributor of cancer-specific mortality. Although remarkable enhancement has been 
achieved in the treatment of neuroblastoma in patients with early stage disease, limited progress has been made 
in the treatment of patients with high-risk neuroblastoma. Thus, innovative approaches are required to achieve 
further improvements in neuroblastoma patient survival outcomes. The major alkaloid obtained from <i>Sophora 
flavescens</i> Ait, matrine, has been shown to counteract malignancy in various kinds of cancers. In the current 
study, we evaluated the effects of matrine on the migration and proliferation of neuroblastoma cells. Cell cycle 
analysis coupled with Transwell and wound healing experiments showed that matrine triggers G<sub>2</sub>/M cell cycle 
arrest and suppresses neuroblastoma migration. This effect of matrine is due to upregulation of TRB3 expression followed by inhibition of the PI3K/AKT activation. Consistent with the in vitro data, growth of xenograft 
cancer was also suppressed by matrine. Our results indicate that matrine inhibits neuroblastoma cell proliferation and migration by enhancing TRB3 expression, suggesting that matrine may serve as a promising agent for 
the treatment of neuroblastoma.},
DOI = {10.3727/096504018X15168461629558}
}