@Article{096504017X15021536183526,
AUTHOR = {Jing Feng},
TITLE = {Upregulation of MicroRNA-4262 Targets Kaiso (ZBTB33) to Inhibit the  Proliferation and EMT of Cervical Cancer Cells},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {8},
PAGES = {1215--1225},
URL = {http://www.techscience.com/or/v26n8/56737},
ISSN = {1555-3906},
ABSTRACT = {More and more studies have reported that dysregulation of microRNAs (miRNAs) leads to the proliferation 
and EMT of multiple cancers. Recently, several reports have demonstrated that dysregulation of miR-4262 
occurs in numerous cancers. However, its role and precise mechanism in human cervical cancer (CC) have 
not been well clarified. Hence, this study aimed to explore the biological roles and precise mechanisms of 
miR-4262 in CC cell lines. The level of miR-4262 was found to be significantly decreased in CC tissues and 
cell lines. Moreover, decreased expression of miR-4262 was closely related to increased expression of Kaiso 
(ZBTB33), which belongs to the BTB/POZ family, in CC tissues and cell lines. The proliferation and EMT of 
CC cells were inhibited by a miR-4262 mimic. However, downregulation of miR-4262 enhanced the proliferation and EMT of CC cells. Next, bioinformatics analysis predicted that miR-4262 might directly target the 
Kaiso gene. Besides, luciferase reporter assay had confirmed this result. Moreover, introduction of Kaiso in CC 
cells partially blocked the effects of miR-4262 mimic. In conclusion, miR-4262 suppressed the proliferation 
and EMT of CC cells by directly downregulating Kaiso.},
DOI = {10.3727/096504017X15021536183526}
}