@Article{096504018X15179661552702,
AUTHOR = {Jian Jiang, Xuewen Song, Jing Yang, Ke Lei, Yongan Ni, Fei Zhou, Lirong Sun},
TITLE = {Triptolide Inhibits Proliferation and Migration of Human Neuroblastoma  SH-SY5Y Cells by Upregulating MicroRNA-181a},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {8},
PAGES = {1235--1243},
URL = {http://www.techscience.com/or/v26n8/56753},
ISSN = {1555-3906},
ABSTRACT = {Neuroblastoma is the primary cause of cancer-related death for children 1 to 5 years of age. New therapeutic 
strategies and medicines are urgently needed. This study aimed to investigate the effects of triptolide (TPL), 
the major active component purified from <i>Tripterygium wilfordii</i> Hook F, on neuroblastoma SH-SY5Y cell 
proliferation, migration, and apoptosis, as well as underlying potential mechanisms. We found that TPL inhibited SH-SY5Y cell viability, proliferation, and migration, but induced cell apoptosis. The expression of matrix 
metalloproteinase-2 (MMP-2) and MMP-9 after TPL treatment in SH-SY5Y cells was decreased. The expression of microRNA-181a (miR-181a) was upregulated after TPL treatment. Moreover, suppression of miR-181a 
reversed the effects of TPL on SH-SY5Y cell proliferation, apoptosis, and migration. Overexpression of miR-
181a enhanced the TPL-induced activation of p38 mitogen-activated protein kinase (p38MAPK) and nuclear 
factor k light chain enhancer of activated B cells (NF-kB) pathways. In conclusion, our research verified that 
TPL inhibited the proliferation and migration of human neuroblastoma SH-SY5Y cells by upregulating the 
expression of miR-181a.},
DOI = {10.3727/096504018X15179661552702}
}