@Article{096504018X15185735627746,
AUTHOR = {Ning Wang, Yang Zhang, Huaxin Liang},
TITLE = {MicroRNA-598 Inhibits Cell Proliferation and Invasion of Glioblastoma by  Directly Targeting Metastasis Associated in Colon Cancer-1 (MACC1)},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {8},
PAGES = {1275--1283},
URL = {http://www.techscience.com/or/v26n8/56757},
ISSN = {1555-3906},
ABSTRACT = {The dysregulation of microRNA (miRNA) expression is closely related with tumorigenesis and tumor 
development in glioblastoma (GBM). In this study, we found that miRNA-598 (miR-598) expression was 
significantly downregulated in GBM tissues and cell lines. Restoring miR-598 expression inhibited cell 
proliferation and invasion in GBM. Moreover, we validated that metastasis associated in colon cancer-1 
(MACC1) is a novel target of miR-598 in GBM. Restoring MACC1 expression reversed the inhibitory 
effects of miR-598 overexpression on GBM cells. In addition, miR-598 overexpression suppressed Met/
AKT pathway activation in GBM. Our results provided compelling evidence that miR-598 serves tumorsuppressive roles in GBM and that its antioncogenic effects are mediated chiefly through the direct suppression of MACC1 expression and regulation of the Met/AKT signaling pathway. Therefore, miR-598 is a 
potential target in the treatment of GBM.},
DOI = {10.3727/096504018X15185735627746}
}