@Article{096504018X15180508535835,
AUTHOR = {Qiaorong Li, Geng Wang, Hong Wang},
TITLE = {miR-126 Functions as a Tumor Suppressor by Targeting SRPK1  in Human Gastric Cancer},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {9},
PAGES = {1345--1353},
URL = {http://www.techscience.com/or/v26n9/56764},
ISSN = {1555-3906},
ABSTRACT = {The expression of miR-126 and serine–arginine protein kinase 1 (SRPK1) are linked to tumor development; 
nevertheless, its role in the tumor growth and invasion of gastric cancer (GC) and the underlying mechanism 
have not been clarified. Here the expression and role of miR-126 and SRPK1 were investigated in GC tissues 
and cells by in vitro assay, and then targets of miR-126 were identified by dual-luciferase reporter assay. In this 
study, miR-126 expression was downregulated and associated with lymph node metastasis and poor prognosis 
as well as SRPK1 expression. In vitro assay revealed that miR-126 obviously inhibited the proliferative and 
invasive capabilities of GC cells. The dual-luciferase reporter assay showed that miR-126 targets the 3'-UTR 
of SRPK1 and downregulates its expression. SRPK1 overexpression promoted cell migration and invasion. In 
conclusion, the reduced expression of miR-126 is suggestive of the risk of GC recurrence and metastasis, and 
miR-126 functions as a tumor suppressor by targeting SRPK1 expression in the development of GC.},
DOI = {10.3727/096504018X15180508535835}
}