@Article{096504018X15188340975709,
AUTHOR = {Ying Ye, Yanan Song, Juhua Zhuang, Saifei He, Jing Ni, Wei Xia},
TITLE = {Long Noncoding RNA CCAL Promotes Papillary Thyroid Cancer  Progression by Activation of NOTCH1 Pathway},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {9},
PAGES = {1383--1390},
URL = {http://www.techscience.com/or/v26n9/56768},
ISSN = {1555-3906},
ABSTRACT = {Long noncoding RNA CCAL has been reported to promote tumor progression in various human cancers, 
including hepatocellular carcinoma, osteosarcoma, and colorectal cancer. However, the role of CCAL in papillary thyroid cancer remains largely unknown. In the present study, we found that the expression of CCAL was 
upregulated in papillary thyroid tumor tissues compared to adjacent normal tissues. Moreover, the expression 
of CCAL was positively related with papillary thyroid cancer severity and TNM stage and predicated poor 
prognosis. Besides, we found that knockdown of CCAL significantly inhibited papillary thyroid cancer cell 
proliferation, migration, and invasion in vitro and reduced tumor growth and metastasis in vivo. We found that 
knockdown of CCAL dramatically decreased the expression of NOTCH1 and suppressed the activation of the 
NOTCH1 signaling pathway. Furthermore, overexpression of NOTCH1 rescued the proliferation, migration, 
and invasion in papillary thyroid cancer cells. Taken together, our data indicated that CCAL promoted papillary 
thyroid cancer development and progression by activation of the NOTCH1 pathway, which provided a new 
insight on the design of therapeutic targets.},
DOI = {10.3727/096504018X15188340975709}
}