@Article{096504018X15178798885361,
AUTHOR = {Zeng Cheng Zou, Min Dai, Zeng Yin Huang, Yi Lu, He Ping Xie, Yi Fang Li, Yue Li, Ying Tan, Feng Lin Wang},
TITLE = {MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular  Carcinoma by Repressing ANXA2R},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {9},
PAGES = {1391--1399},
URL = {http://www.techscience.com/or/v26n9/56769},
ISSN = {1555-3906},
ABSTRACT = {The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly 
understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues 
compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 
cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo 
mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the 
expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these 
results demonstrated that miR-139-3p inhibited the metastasis process in HCC by downregulating ANXA2R 
expression.},
DOI = {10.3727/096504018X15178798885361}
}