TY  - EJOU
AU  - Zou, Zeng Cheng 
AU  - Dai, Min 
AU  - Huang, Zeng Yin 
AU  - Lu, Yi 
AU  - Xie, He Ping 
AU  - Li, Yi Fang 
AU  - Li, Yue 
AU  - Tan, Ying 
AU  - Wang, Feng Lin 

TI  - MicroRNA-139-3p Suppresses Tumor Growth and Metastasis in Hepatocellular  Carcinoma by Repressing ANXA2R
T2  - Oncology Research

PY  - 2018
VL  - 26
IS  - 9
SN  - 1555-3906

AB  - The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly 
understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly reduced in the HCC tissues 
compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 
cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo 
mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the 
expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these 
results demonstrated that miR-139-3p inhibited the metastasis process in HCC by downregulating ANXA2R 
expression.
KW  - MicroRNA 139-3p (miR-139-3p); Hepatocellular carcinoma (HCC);  Annexin A2 receptor (ANXA2R); Metastasis

DO  - 10.3727/096504018X15178798885361