@Article{096504018X15188747585738,
AUTHOR = {Jian Shen, Minzhe Li},
TITLE = {MicroRNA-744 Inhibits Cellular Proliferation and Invasion of Colorectal  Cancer by Directly Targeting Oncogene Notch1},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {9},
PAGES = {1401--1409},
URL = {http://www.techscience.com/or/v26n9/56770},
ISSN = {1555-3906},
ABSTRACT = {Accumulated studies have strongly implicated aberrantly expressed microRNAs (miRNAs) in carcinogenesis 
and cancer progression of various cancers, including colorectal cancer (CRC). Hence, a comprehensive study 
of miRNAs and their association with CRC may be a promising therapeutic method for patients with this 
malignancy. MicroRNA-744 (miR-744) is abnormally expressed in several types of human cancer. Thus far, 
little is known about the expression, biological roles, and exact mechanisms of miR-744 in CRC. Thus, the 
present study measured the expression level of miR-744 and investigated its roles and associated molecular 
mechanisms in CRC. This study demonstrated that miR-744 expression was significantly underexpressed in 
CRC tissues and cell lines. Low miR-744 expression was positively associated with lymphatic metastasis and 
TNM stage. Functional experiments revealed that miR-744 overexpression obviously inhibited the proliferation and invasion of CRC cells. Furthermore, Notch1 was identified as a direct target of miR-744 in CRC. 
Moreover, the inhibition of Notch1 phenocopied the inhibitory effects of miR-744 overexpression on CRC 
cells. Restored Notch1 expression markedly rescued the tumor-suppressive effects of miR-744 overexpression 
on CRC cells. Overall, miR-744 exhibits an essential role in CRC progression, and the miR-744/Notch1 axis 
may provide novel insights into future treatments for patients with CRC.},
DOI = {10.3727/096504018X15188747585738}
}