@Article{096504018X15193823766141,
AUTHOR = {Quan Shi, Qi He, Jing Wei},
TITLE = {MicroRNA-342 Prohibits Proliferation and Invasion of Melanoma Cells by Directly Targeting Zinc-Finger E-Box-Binding Homeobox 1},
JOURNAL = {Oncology Research},
VOLUME = {26},
YEAR = {2018},
NUMBER = {9},
PAGES = {1447--1455},
URL = {http://www.techscience.com/or/v26n9/56775},
ISSN = {1555-3906},
ABSTRACT = {As documented in numerous studies, microRNAs (miRNAs) play key roles in various biological processes 
associated with melanoma occurrence and development. In this study, we found that miRNA-342 (miR-342) 
was significantly downregulated in melanoma tissues and cell lines. Additionally, the ectopic expression of 
miR-342 prohibited the cell proliferation and invasion of melanoma. Moreover, zinc-finger E-box-binding 
homeobox 1 (ZEB1) was identified as a direct target gene of miR-342 in melanoma. Similar with the results 
induced by miR-342 overexpression, ZEB1 knockdown attenuated cell proliferation and invasion in melanoma. 
Furthermore, the restoration of ZEB1 expression reversed the suppressive effects of miR-342 on the proliferation and invasion of melanoma cells. These findings suggest that miR-342 may play tumor-suppressing roles in 
melanoma, at least partially, by directly inhibiting ZEB1 expression. Therefore, miR-342 may be developed as 
a potential candidate for the treatment of patients with this aggressive type of cancer.},
DOI = {10.3727/096504018X15193823766141}
}