@Article{096504018X15193469240508,
AUTHOR = {Lihua Jiang,
 Wenchuan Yang,
 Weishi Bian, Hailin Yang, Xia Wu, Yuhua Li, 
Wen Feng, Xuejian Liu},
TITLE = {MicroRNA-623 Targets Cyclin D1 to Inhibit Cell Proliferation and Enhance  the Chemosensitivity of Cells to 5-Fluorouracil in Gastric Cancer},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {1},
PAGES = {19--27},
URL = {http://www.techscience.com/or/v27n1/48656},
ISSN = {1555-3906},
ABSTRACT = {The dysregulation of microRNAs (miRNAs) plays an important function in the onset and progression of gastric 
cancer (GC). In addition, aberrantly expressed miRNAs affect the chemosensitivity of GC cells to chemotherapeutic drugs. Hence, miRNA-based targeted therapy might be applied to treat patients with GC exhibiting chemotherapeutic resistance. In this study, miRNA-623 (miR-623) expression was downregulated in GC tissues 
and cell lines. Functional analysis showed that the restored miR-623 expression could inhibit the proliferation 
of GC cells and enhance their chemosensitivity to 5-FU via the cell apoptosis pathway. Cyclin D1 (CCND1) 
was identified as a direct target gene of miR-623 in GC. The overexpressed CCND1 in GC tissues was negatively correlated with miR-623 level. The recovered CCND1 expression counteracted the effects of miR-623 
on GC cell proliferation, chemosensitivity, and 5-FU-induced apoptosis. Thus, our results suggest that miR-623 
might function as a tumor suppressor in GC and could be a promising therapeutic target for patients with GC, 
especially those with chemotherapeutic resistance.},
DOI = {10.3727/096504018X15193469240508}
}