@Article{096504018X15199482824130,
AUTHOR = {Zhenjun Liu, Pei Zhao, Yuping Han, Song Lu},
TITLE = {lncRNA FEZF1-AS1 Is Associated With Prognosis in Lung Adenocarcinoma  and Promotes Cell Proliferation, Migration, and Invasion},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {1},
PAGES = {39--45},
URL = {http://www.techscience.com/or/v27n1/48658},
ISSN = {1555-3906},
ABSTRACT = {Long noncoding RNAs (lncRNAs) have been reported to play important roles in tumorigenesis. In the present study, we demonstrated that lncRNA forebrain embryonic zinc finger protein 1 (FEZF1) antisense RNA1 
(FEZF1-AS1) is markedly upregulated in human lung adenocarcinoma (LAD) tissues and cell lines and is 
associated with poor prognosis. Loss of function revealed that deletion of FEZF1-AS1 expression significantly 
inhibited the LAD cell proliferation, invasion, and migration. Further studies revealed that downregulation of 
FEZF1-AS1 reduced mRNA and protein expression of its sense-cognate gene FEZF1 in LAD cells, and vice 
versa. Correlation analysis indicated that there was a positive correlation between FEZF1-AS1 and FEZF1 
expression in LAD tissues. Additionally, rescue assay confirmed that the function of FEZF1-AS1 in LAD was 
mediated by FEZF1. Our findings suggested that dysregulation of FEZF1-AS1 contributed to the progression 
of LAD, which might be a potential target for LAD therapy.},
DOI = {10.3727/096504018X15199482824130}
}