@Article{096504018X15193843443255,
AUTHOR = {Jia Yu, Qiyu Fang, Shuyan Meng},
TITLE = {Knockdown of Long Noncoding RNA ENST457720 Inhibits Proliferation of  Non-Small Cell Lung Cancer Cells In Vitro and In Vivo},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {1},
PAGES = {47--53},
URL = {http://www.techscience.com/or/v27n1/48659},
ISSN = {1555-3906},
ABSTRACT = {Non-small cell lung cancer (NSCLC) represents the leading cause of cancer-related mortality worldwide. More 
and more reports have identified important roles for long noncoding RNAs (lncRNAs) in cancer development. 
ENST457720 expression was upregulated in lung adenocarcinoma in a microarray-based lncRNA screen. We 
determined the expression levels of ENST457720 in NSCLC tissues with quantitative real-time PCR and then 
studied their clinical significance. We explored the biological significance of ENST457720 with gain- and lossof-function analyses in vitro and in vivo. In this study, ENST457720 was expressed at higher levels in NSCLC 
tissues than in paired normal tissues. Higher ENST457720 expression was associated with larger tumor sizes, 
lymph node metastasis, and advanced TNM stage. ENST457720 silencing suppressed NSCLC cell proliferation in vitro and in vivo. Moreover, ENST457720 knockdown inhibited NSCLC invasion and reversed the 
epithelial-to-mesenchymal transition. ENST457720 promoted NSCLC proliferation and invasion, which may 
be a novel potential therapeutic target for NSCLC.},
DOI = {10.3727/096504018X15193843443255}
}