@Article{096504018X15191223015016,
AUTHOR = {Yuping Peng, Xuning Shen, Honggang Jiang, Zhiheng Chen, Jiaming Wu, Yi Zhu, Yuan Zhou, Jin Li},
TITLE = {miR-188-5p Suppresses Gastric Cancer Cell Proliferation  and Invasion via Targeting ZFP91},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {1},
PAGES = {65--71},
URL = {http://www.techscience.com/or/v27n1/48661},
ISSN = {1555-3906},
ABSTRACT = {MicroRNAs (miRNAs) have been demonstrated to be essential regulators in the development and progression 
of various cancers. The role of miR-188-5p in gastric cancer (GC) has not been determined. In this study, we 
found that the expression of miR-188-5p was downregulated in GC tissues compared with adjacent normal tissues. The lowly expressed miR-188-5p was significantly associated with lymph node metastasis and advanced 
TNM stage. Moreover, overexpression of miR-188-5p significantly inhibited GC cell proliferation, migration, 
and invasion but promoted cellular apoptosis. Mechanistically, we identified transcription factor ZFP91 as a 
target gene of miR-188-5p in GC. We found that miR-188-5p overexpression significantly inhibited the expression of ZFP91 in GC cell lines. There was an inverse correlation between the expression of miR-188-5p and 
ZFP91 in GC tissues. We found that restoration of ZFP91 in miR-188-5p-overexpressed MGC-803 and SGC-
7901 cells promoted cell proliferation, migration, and invasion. Finally, we also showed that overexpression 
of miR-188-5p inhibited tumor growth in vivo. Taken together, our findings indicated that miR-188-5p serves 
as a tumor suppressor in human GC by targeting ZFP91, suggesting that miR-188-5p might be a promising 
therapeutic target for GC treatment.},
DOI = {10.3727/096504018X15191223015016}
}