@Article{096504018X15199511344806,
AUTHOR = {Bo Xia, Lei Wang, Li Feng, Baofang Tian, Yuanjie Tan, Baoyin Du},
TITLE = {Knockdown of Long Noncoding RNA CAT104 Inhibits the Proliferation,  Migration, and Invasion of Human Osteosarcoma Cells by Regulating  MicroRNA-381},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {1},
PAGES = {89--98},
URL = {http://www.techscience.com/or/v27n1/48664},
ISSN = {1555-3906},
ABSTRACT = {Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. This study 
aimed to explore the effects of long noncoding RNA CAT104 and microRNA-381 (miR-381) on osteosarcoma 
cell proliferation, migration, invasion, and apoptosis, as well as the underlying potential mechanism. We found 
that CAT104 was highly expressed in osteosarcoma MG63 and OS-732 cells. Knockdown of CAT104 significantly inhibited OS-732 cell proliferation, migration, and invasion, but promoted cell apoptosis. CAT104 
regulated the expression of miR-381, and miR-381 participated in the effects of CAT104 on OS-732 cells. Zinc 
finger E-box-binding homeobox 1 (ZEB1) was a direct target gene of miR-381, which was involved in the 
regulatory roles of miR-381 in OS-732 cell proliferation, migration, invasion, and apoptosis, as well as c-Jun 
N-terminal kinase (JNK) and Wnt/ -catenin pathways. In conclusion, our research verified that suppression of 
CAT104 exerted significant inhibitory effects on osteosarcoma cell proliferation, migration, and invasion by 
regulating the expression of miR-381 and downstream ZEB1, as well as JNK and Wnt/ -catenin pathways.},
DOI = {10.3727/096504018X15199511344806}
}