@Article{096504017X15021536183517,
AUTHOR = {Zheng-Gang Chen, Chuan-Yi Zheng, Wang-Qing Cai, Da-Wei Li, Fu-Yue Ye, 
Jian Zhou, Ran Wu, Kun Yang},
TITLE = {miR-26b Mimic Inhibits Glioma Proliferation In Vitro  and In Vivo Suppressing COX-2 Expression},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {2},
PAGES = {147--155},
URL = {http://www.techscience.com/or/v27n2/48639},
ISSN = {1555-3906},
ABSTRACT = {Glioma is the most common malignant tumor of the nervous system. Studies have shown the microRNA-26b 
(miR-26b)/cyclooxygenase-2 (COX-2) axis in the development and progression in many tumor cells. Our study 
aims to investigate the effect and mechanism of the miR-26b/COX-2 axis in glioma. Decreased expression of 
miR-26b with increased levels of COX-2 was found in glioma tissues compared with matched normal tissues. 
A strong negative correlation was observed between the level of miR-26b and COX-2 in 30 glioma tissues. The 
miR-26b was then overexpressed by transfecting a miR-26b mimic into U-373 cells. The invasive cell number 
and wound closing rate were reduced in U-373 cells transfected with miR-26b mimic. In addition, COX-2 
siRNA enhanced the effect of miR-26b mimic in suppressing the expression of p-ERK1 and p-JNK. Finally, 
the in vivo experiment revealed that miR-26b mimic transfection strongly reduced the tumor growth, tumor 
volume, and expression of matrix metalloproteinase-2 (MMP-2) and MMP-9. Taken together, our research 
indicated a miR-26b/COX-2/ERK/JNK axis in regulating the motility of glioma in vitro and in vivo, providing 
a new sight for the treatment of glioma.},
DOI = {10.3727/096504017X15021536183517}
}