@Article{096504018X15190861873459,
AUTHOR = {Kejun Wang,
 Lin Yan, Fen Lu},
TITLE = {miR-363-3p Inhibits Osteosarcoma Cell Proliferation and Invasion  via Targeting SOX4},
JOURNAL = {Oncology Research},
VOLUME = {27},
YEAR = {2019},
NUMBER = {2},
PAGES = {157--163},
URL = {http://www.techscience.com/or/v27n2/48640},
ISSN = {1555-3906},
ABSTRACT = {miR-363-3p has been shown to suppress tumor growth and metastasis in various human cancers. However, the 
function of miR-363-3p in osteosarcoma (OS) has not been determined. In our study, we found that the expression of miR-363-3p was significantly downregulated in OS tissues compared with adjacent normal tissues. 
miR-363-3p expression was associated with the poor overall survival rate of OS patients. Moreover, we found 
that overexpression of miR-363-3p markedly inhibited the proliferation, migration, and invasion of U2OS and 
MG63 cells. Moreover, we found that SOX4 was a direct target of miR-363-3p in OS cells. Overexpression 
of miR-363-3p significantly inhibited the expression of SOX4. Expression levels of miR-363-3p and SOX4 
were negatively correlated in OS tissues. Finally, we found that restoration of SOX4 attenuated the suppressive 
effects of miR-363-3p on the proliferation, migration, and invasion of U2OS and MG63 cells. Therefore, our 
findings demonstrated that miR-363-3p served as a tumor suppressor in OS tissues by targeting SOX4.},
DOI = {10.3727/096504018X15190861873459}
}